haoxing xu google scholar

The pore-forming subunits of canonical voltage-gated sodium and calcium channels are encoded by four repeated domains of six-transmembrane (6TM) segments. Ca 2+ /calmodulin signals the completion of docking and triggers a late step of vacuole . Abstract Full Pdf; Dec 2020 . He was a postdoctoral fellow in David Clapham's laboratory at Boston Children's Hospital, where he cloned a temperature-sensitive TRP ion channel . The following articles are merged in Scholar. Lab Members. Bioessays. Add co-authors Co-authors. Carbohydrate Polymers 257, 117598, 2021. Their combined citations are counted only for the first article. Methods in Cell Biology 126:159-195. . Proceedings of the ACM on Interactive, Mobile, Wearable and Ubiquitous …. J Yang, Z Zhao, M Gu, X Feng, H Xu. Their combined citations are counted only for the first . Using Arabidopsis transgenic plant expressing the PI(3,5)P 2-labeling . Given TRPML1's proposed roles in lysosomal membrane trafficking and cellular clearance [], we used Ca 2+ imaging and electrophysiological assays to screen for potential TRPML1 modulators from a list of natural products that are known to affect lysosome function or autophagy.Whole-endolysosome recordings were performed in vacuoles that . View author publications. Abstract. (Sigma; also known as ML-SI1, Haoxing Xu, Department of Molecular, Cellular, and Developmental Biology, University of Michigan, USA, personal communication), ML-SI3 (a kind gift from Haoxing Xu), MK6-83 synthesised as described previously . 136 . Short-Term Traffic Flow Forecasting with Spatial-Temporal Correlation in a Hybrid Deep Learning Framework. View author publications. The ones marked * may be different from the article in the profile. Google Scholar. Protein & cell 10 (1), 8-19, 2019. 63: 2019: Spatial sequestration and detoxification of Huntingtin by the ribosome quality . Assistant Professor, Beijing University of Posts and Telecommunications. The following articles are merged in Scholar. You can also search for this author in PubMed Google . Epithelial homeostasis and regeneration require a pool of quiescent cells. Qiong Gao. The degradation of RNF152 depends . Search for other works by this author on: This Site . Yamin Gong, Yamin Gong . 926: [Jingyu Pan, Chen-Chia Chang, Zhiyao Xie, Ang Li, Minxue Tang, Tunhou Zhang, Jiang Hu, and Yiran Chen."Towards Collaborative Intelligence: Routability Estimation based on Decentralized Private Data". The following articles are merged in Scholar. Article Google Scholar RAHNEJAT H, BALAKRISHNAN S, KING P D, et al. Neurons were plated onto coverslips and maintained in Neurobasal-A/B27 medium (Invitrogen). How the quiescent cells are established and maintained is poorly understood. 1).MAP decreased after propofol administration in both groups. Address correspondence and reprint requests to Haoxing Xu, The Department of Molecular, Cellular, and Developmental Biology, University of Michigan, 3089 Natural Science Building (Kraus), 830 North University, Ann Arbor, MI 48109, USA. 2018.01.16 - One paper accepted at ICRA 2018. . Haoxing Xu. News. Nat Rev Genet 1: 208-217. Google Scholar Y. Wu and H. Tan. Their combined citations are counted only for the first article . Article Download PDF View Record in Scopus Google Scholar. Other Formats . Follow. Proceedings of the National Academy of Sciences of the United States of America. . Process design and performance analysis of a new type of wear resistant guide plate [J]. Malfunctioning and abnormalities in lysosomes can cause a plethora of neurodegenerative diseases. Nature 418 (6894), 181-186, 2002. C. Peters, A. Mayer. Institute of . Xian-Ping Dong, Xiang Wang, Dongbiao Shen, Su Chen, Meiling Liu, Yanbin Wang, Eric W. Mills, Xiping Cheng, Markus Delling, Haoxing Xu> ;Journal of Biological Chemistry. 5'-Nucleotidase: molecular structure and . The following articles are merged in Scholar. 1 author. Chen C, Zhang HY, Xu YQ, Wu JL (2020) Investigation of the flat-clinching process for joining three-layer sheets on thin-walled structures. Resume/CV | SSRN Author Page | Google Scholar Author Page. The following articles are merged in Scholar. J. Qiuran Xu, 1, † Caihong Yang, 2 Yu Du, 2, 3, † Yali Chen, 3 Hailong Liu, 3 Min Deng, 4 Haoxing Zhang, 3, 4 Lei Zhang, 4 Tongzheng Liu, 4 Qingguang Liu, 1 Liewei Wang, 5, * Zhenkun Lou, 4, * and Huadong Pei 3, * . Direct activation of lysosomal TRPML1 channels by Rap. NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study. Advances in Neural Information Processing Systems 34. , 2021. He was a postdoctoral fellow (HHMI) in David Clapham's laboratory at Children's Hospital, Harvard Medical School in Boston, Massachusetts. 0000-0002-5281-7392 , Qiong Gao 1. Author information. As shown in Fig. SAE International Journal of Fuels and Lubricants, 2013, 6(1): 137-148. The lysosome is an essential organelle to recycle cellular materials and maintain nutrient homeostasis, but the mechanism to down-regulate lysosomal membrane proteins is poorly understood. Dongbiao Shen, Dongbiao Shen 2. Google Scholar; Miroslav Backonja, Mark S Wallace, E Richard Blonsky, Barry J Cutler, Philip Malan Jr, Richard Rauck, Jeffrey Tobias, NGX-4010 C116 Study Group, et al. There were no statistical differences in MAP at any time point between the two groups. The accumulation of neurotoxic amyloid-β (Aβ) plaques contributes to the pathophysiology of AD. Google Scholar. Here we report that Trpv6, a cation channel responsible for epithelial Ca2+ absorption, functions as a key regulator of cellular quiescence. He graduated from Peking University, Beijing, China, and received a PhD from Georgia State University, Atlanta, Georgia. 337: 2018: Multilayer polypyrrole nanosheets with self‐organized surface structures for flexible and efficient solar . 2016. Article lifetime Last 6 months This month Article usage: December 2020 to December 2020. Single image haze removal has been a challenging task due to its super ill-posed nature. [Google Scholar] Articles from Nucleic Acids Research are provided here courtesy of Oxford University Press. However, how this epigenetic modification is regulated remains unclear. Haoxing Xu. Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Single channel conductance of Kir4.1 currents. 2014. Here we used, patch clamp electrophysiology and intracellular Ca 2+ measurements in HEK293 cells and two-electrode voltage clamp electrophysiology in Xenopus oocytes to study the effects of disease-associated mutations on TRPM3 function. After that, neurons were dissociated in Dulbecco's modified Eagle's medium with 10% fetal bovine serum (Invitrogen). and . In this issue, Shang et al. Plasma membrane (PM) disruptions occur in most cells, especially in those residing in mechanically-active environments, such as skeletal and cardiac muscle [1, 2].Resealing is a repair process that allows cells to mend damaged membranes, preventing the loss of terminally-differentiated cells [1, 2].Recent studies have suggested that damaged cells are able to restore the lipid . Materials Review, 2017, . . Shen D, Wang X, Xu H. Pairing phosphoinositides with calcium ions in endolysosomal dynamics: Phosphoinositides control the direction and specificity of membrane trafficking by regulating the activity of calcium channels in the endolysosomes. Yamin Gong, Bin Peng, Ruifeng Shi, Dan Fan, Hongchang Zhao, Min Zhu, Haoxing Zhang, Zhenkun Lou, Jianwei Zhou, Wei-Guo Zhu, Yu-Sheng Cong, Xingzhi Xu, MRE11 UFMylation promotes ATM activation, Nucleic Acids Research, Volume 47, Issue 8, 07 May 2019, . Haixiang Qin, Xuefeng Qiu, Haoxing Ma, Linfeng Xu, Liu Xu, Xiaogong Li & Hongqian Guo. There were no statistical differences in SpO 2 at other time points (Fig. Haoxiang Zhu is Gordon Y Billard Professor of Management and Finance and Associate Professor of Finance at the MIT Sloan School of Management. The transient receptor potential (TRP) protein was first designated in the 1960s as the underlying mediator of impaired visual adaptation in Drosophila, where photoreceptors carrying mutations of the trp gene exhibit a transient voltage response to continuous light illumination (Cosens and Manning, 1969; Minke, 1977; Montell et al., 1985).The trp gene in Drosophila was cloned in the 1980s . CAS PubMed Google Scholar . Article Google Scholar . Alzheimer's disease (AD) is the leading cause of late-onset dementia, and there exists an unmet medical need for effective treatments for AD. Kai Xu, Hui Huang, Yifei Shi, Hao Li, Pinxin Long, Jianong Caichen, Wei Sun, Baoquan Chen ACM Transactions on Graphics (SIGGRAPH Asia 2015), 2015 project . We appreciate the encouragement and helpful comments from other members of the Dong laboratory and El Hiani laboratories. Article Google Scholar XU M, ZHANG Y Y, ZENG W, et al. Google Scholar. SLC17A9 deficiency reduced lysosome ATP accumulation and compromised lysosome function, resulting in cell death. Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109. Follow this author. Notably, lysosomal adaptation is required for cell survival under low nutrient conditions. Haoxing Pan 1 Journal of . 2007; 104:18321-18326. We expressed and characterized a bacterial ion channel (NaChBac) from Bacillus halodurans that is encoded by one 6TM segment. Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth and is localized on the lysosomal surface when free AAs are abundant via a Rag GTPase-dependent mechanism (10, 11).The activity of lysosome-localized mTORC1 is tightly controlled by Rheb GTPase, which, in turn, is regulated by growth factors in the serum (). Hongchang Xu, Zhiyuan Yuan & Haoxing Pan. Article lifetime Last 6 months This month Article usage: December 2020 to December 2020. Here we set out to study vesicular exocytosis and glutamate release in mouse . . arXiv preprint arXiv:1612.01022(2016). Google Scholar; Article usage. Andrews NC (2000) Iron homeostasis: Insights from genetics and animal models. Google Scholar. We thank Mitsunori Fukuda for the Syt-VII-DN plasmid and Haoxing Xu for his constant support. . . In-cylinder friction reduction using a surface finish optimization technique [J]. . Z Xu, AB Ji, A Woods, B Chen, A Shrivastava. Edited by Haoxing Xu, University of Michigan, Ann Arbor, MI, and accepted by Editorial Board Member Alan Hastings October 2, 2020 (received for review March 11, 2020) . The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. [PMC free article] [Google Scholar] EPHX2 encoding soluble epoxide hydrolase (sEH)—a key enzyme for epoxyeicosatrienoic acid (EET) signaling that is mainly expressed in lysosomes of . Article CAS PubMed PubMed Central Google Scholar Dong, X. P. et al. TM-induced and tissue-specific Trpm7 disruption reveals a spatiotemporal requirement of the channel kinase for embryogenesis. Haoxing Xu; The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. In arXiv, 2022. [Google Scholar] Berg, I . Introduction. Although the functions of these molecules, from regulating synaptic transmission to controlling specific behavior, are well documented, the identity of their cellular compartment(s) is still unclear. . . IEEE Design & Test 38 (2), 19-26, 2020. Article . Advanced Functional Materials 25 (34), 5537-5547. CAS Google Scholar Li, X. J. et al. These residual cognitive impairments may involve aberrant deposition of amyloid β-peptides (Aβ). Xu H 4, Merchant JL 5. Specification of motoneurons from human embryonic stem cells. Youcheng Pan. New articles by this author. Astrocytes release a variety of signaling molecules including glutamate, d-serine, and ATP in a regulated manner. Proceedings of the 18th International Conference on Mobile Systems …. 6. Costunolide, a sesquiterpene isolated from Vladimiria souliei (Franch.) Barry MJ, Gallagher PM, Skinner JS, Fowler FJ Jr (2012) Adverse effects of robotic-assisted laparoscopic versus open retropubic radical prostatectomy among a nationwide random sample of medicare-age men. SHAO C M, MI G F, XU L, et al. Their combined citations are counted only for . Haoxing Xu Professor at the University of Michigan Verified email at umich.edu. A, single channel current was recorded from an inside-out patch using symmetric concentrations of K + (150 mM) on each side of the patch at various membrane potentials (V m).While there is no channel activity at depolarizing potentials, an active channel is seen at hyperpolarizing V m.Continuous line, open state; dotted line, closed state. This "Cited by" count includes citations to the following articles in Scholar. . Google Scholar; Vriens J; Owsianik G; Janssens A; Voets T; Nilius B (2007) Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4. Here we . Authors. Xu H, Delling M, Li L, Dong X, Clapham DE. Abstract Full Pdf; Dec 2020 . Zhiyao Xie, Jingyu Pan, Chen-Chia Chang, Yiran Chen."The Dark Side: Security Concerns in Machine Learning for EDA". Christian Grimm, Christian Grimm 2. He is also a Research Associate at the National Bureau of Economic Research, a Faculty Affiliate of the MIT Golub Center for Finance and Policy . Department of Molecular, Cellular and Developmental Biology, University of Michigan Medical School, . in the authors' laboratory is supported by startup funds to H.X. Marlene Azar, Wai Lok Tsang, Libing Dong, Nirakar Sahoo, Xinran Li, Yue Zhuo, Abigail G Garrity, Xiang Wang & Haoxing Xu. As for the "ER NAADP signaling model", the role of TPCs as Ca 2+ channels has also been questioned—Haoxing Xu and colleagues demonstrated that TPCs are Na + channels that are regulated by phosphatidylinositol 3,5-bisphosphate, but not by NAADP . We are also grateful to Lin Mei for CaM-Myc-His plasmid and Michael X. Zhu for TPC2-mCherry and Lamp1-mCherry. 1. Qingfeng . Mutations of the lysosomal Ca[2+] channel TRPML1 cause lysosome storage disease (LSD) characterized by . The system can't perform the operation now. 17: 2021: Recent advances in development of dendritic polymer‐based nanomedicines . from the Department of MCDB and . Search for other works by this author on: This Site. 23, 215-221 (2005). . H Xu, IS Ramsey, SA Kotecha, MM Moran, JA Chong, D Lawson, P Ge, . Haoxing Xu Professor at the University of Michigan Verified email at umich . (A) Trpm7 is temporally required for embryogenesis. Haoxing Xu. Teun Munnik, Teun Munnik 3 Section of Plant Physiology, Swammerdam Institute for Life Sciences, University of Amsterdam, . Chem. 2009 Nov 13 349 citations The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel Center for Integrated Protein Science CIPSM. . Dongbiao Shen, Haoxing Xu, Andrew P. Lieberman, Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann-Pick type C disease fibroblasts, Human Molecular . In this study, we identified TRPML1, a lysosomal Ca2+-permeant ion channel . Publications. H Chen, M Liu, B Xu, K Zhu, X Tang, S Li, Y Lin, N Sun, DZ Pan. Consequently, understanding the structural information on lysosomes down to a subnanometer level is essential. 7: 2020: Qiuran Xu, 1, † Caihong Yang, 2 Yu Du, 2, 3, † Yali Chen, 3 Hailong Liu, 3 Min Deng, 4 Haoxing Zhang, 3, 4 Lei Zhang, 4 Tongzheng Liu, 4 Qingguang Liu, 1 Liewei Wang, 5, * Zhenkun Lou, 4, * and Huadong Pei 3, * . . Satellite Images and Deep Learning to Identify Discrepancy in Mailing Addresses with Applications to Census 2020 in Houston. The accumulation of misfolded proteins is a common pathological feature of many neurodegenerative disorders, including synucleinopathies such as Parkinson's disease (PD), which is characterized by the presence of α-synuclein (α-syn)-containing Lewy bodies. Changes of PIP levels regulate the trafficking of vesicles and the activity of membrane transport proteins. Haoxing Guo, Ke Zhao, 2010 - 2011 By unknown mechanisms, Aβ accumulates in the lysosomal and autophagic compartments of neurons in the HIV-infected brain. Dr. Xu joined the MCDB faculty in 2007 and has won mutiple faculty awards . The ones marked * may be different from the article in the profile. NKD Haoxing Wu , Brandon T. Cisneros , Christian M. Cole. Hao Chen. Verified email at umich.edu . Phosphatidylinositol 3,5-bisphosphate [PI(3,5)P 2] is a low-abundance phospholipid known to be associated with a wide variety of physiological functions in plants.However, the localization and dynamics of PI(3,5)P 2 in plant cells remain largely unknown, partially due to the lack of an effective fluorescent probe. Nature Biotechnol. After timed breeding [male Trpm7 fl/fl (Cre-ER) mice with female Trpm7 fl/fl mice], TM was . Antiretroviral therapy extends the lifespan of human immunodeficiency virus (HIV)-infected patients, but many survivors develop premature impairments in cognition. Authors. More concretely, we redefine a more reliable atmospheric scattering model (ASM) based on our previous work and the atmospheric point spread function (APSF). Other Formats . J Bao, X Xu, C Zhang, Y Li, H Wu, Z Gu. Google Scholar 2. Of particular relevance is the significant increase in the endogenous levels of reactive oxygen species (ROS). Dr. Xu received his BS from Peking University (Beijing, China) and Ph.D. from Georgia State University in Atlanta, Georgia. 40 Very importantly, the seminal work of Xu's group showed a direct and specific activation of lysosomal TRPML1 channel by ROS 12 that may lead to the autophagy-mediated removal of damaged organelles 12, 41 and, in turn, excessive ROS . Zhen Wang, 1 , 4 Ramon Ocadiz-Ruiz, 1 Sinju Sundaresan, 1 Lin Ding, 1 Michael Hayes, 1 Nirakar Sahoo, 3 Haoxing Xu, 1 , 2 and Juanita L. Merchant 1 , 2 , 5 . [Google Scholar] Articles from Nucleic Acids Research are provided here courtesy of Oxford University Press. H. Zimmermann. Professor at the University of Michigan. 2021. Affiliations. Haoxing Ren (Mark) Nvidia Verified email at nvidia.com. made an unexpected observation while performing a negative control experiment in their study of TRPA1-mediated Ca 2+ responses: Complete removal of external Ca 2+ failed to abolish AITC-induced [Ca 2+] i increase and neuropeptide release in DRG neurons. . Mengwei Xu. 2021. Contributed equally to this work with: Haoxing Xu, Jie Jin Affiliation Howard Hughes Medical Institute, Children's Hospital, Harvard Medical School, Boston, Massachusetts, United . 2011; 33 (6):448-457. Histone H2B O-GlcNAcylation is an important post-translational modification of chromatin during gene transcription. Haoxing Ren (Mark) Nvidia Verified email at nvidia.com. Article Google Scholar . Xian-Ping Dong, Xiping Cheng, Eric Mills & Haoxing Xu The Department of Cardiology, Children's Hospital Boston, Enders 1350, 320 Longwood Avenue, Boston, Massachusetts 02115, USA Markus Delling In this study, we developed a cycloheximide chase assay to measure the half-lives of ~30 human lysosomal membrane proteins, and identified RNF152 as a short-lived protein. Article Download PDF View Record in Scopus Google Scholar. . T Wang, Y Zhang, Q Liu, W Cheng, X Wang, L Pan, B Xu, H Xu. Their combined citations are counted only for the first article. Biocompatible PEG‐Chitosan@ Carbon Dots Hybrid Nanogels for Two‐Photon Fluorescence Imaging, Near‐Infrared Light/pH Dual‐Responsive Drug Carrier, and Synergistic Therapy. . Proceedings of the 24th Annual International Conference on Mobile Computing ….

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